Jackbox broke the news in a recent blog post, where the game was detailed a bit further. According to Jackbox, a sequel to Trivia Murder Party is the most-requested of them all, and it's finally coming as of Party Pack 6. The game centers around trivia, of course (as you probably already guessed) where if you answer the question wrong, you have to fight for your life against a serial killer with various different mini-games.
The Jackbox Party Pack is always full of hilarious times for anyone who gets involved, and Trivia Murder Party 2 is coming to make it rain.blood, probably.